All of the cannabinoids are fat-soluble substances and accumulate in tissues rich in lipids: the brain, lungs, genital organs, as well as in cell membranes. Penetrating through the walls of the membranes in the cell nucleus cannabinoids induce changes in biochemical processes and cell metabolism, disrupting the processes of synthesis of DNA, RNA and cellular proteins. As a result of cell activity decreases or stops, which has the effect of suppressing the corresponding functions.

With its lipophilic properties, after the introduction into the body cannabinoids accumulate in fatty tissue. Release into the circulatory system is slow, as a result they can be detected in the body over a long period of time even after a single use.
Effects due to the use of marijuana

Marijuana has on the body stimulating and sedative effects of Noe, supplemented with higher doses, hallucinogenic effects.

PHYSIOLOGICAL EFFECTS OF MARIJUANA
o swelling of the lining eyes, sore eyes
o Increased heart rate, palpitation
o an increase in blood pressure
o mobility impairments
o relaxation
o fluctuations in body temperature
o headache
o dizziness
o nausea
o sensation of hunger

BEHAVIORAL EFFECTS OF MARIJUANA
o Relaxation
o reduction of psychomotor activity
o impairment of concentration, impaired ability to correctly assess the distance
o Reduced ability to drive a car and other opera sequence that requires attention
o rapid speech, unrestrained loquacity

Emotional effect
o euphoria, a feeling of well-being
o carefree state, alternating with
o state of anxiety and worry

Neuropsychiatry effects
o deterioration in short-term memory, understanding, ability to perform any task
o change in perception of time and space
o enhanced tactile sensitivity
o aggravation of visual and auditory perception of smell
o reduce the pain barrier
o changes in the sexual emotions
o hallucinations
o loss of awareness of themselves as individuals, depersonalization
o psychosis (at high doses)
Toxic manifestations of high-dose

o reduction of muscle
o anxiety
o suspicion
o delirium
o paranoia
o panic mode
o the cerebral circulation
o difficulty with speech
o recurrent hallucinations (sometimes after 6 months of abstinence)

SOCIAL CONSEQUENCES OF PROLONGED USE

o Social withdrawal
o the transition to a more “hard” drugs
o relationship to crime
Tolerance and dependence

Inconsistency of available data causes professional debate about tolerance and dependence as an inevitable consequence of marijuana use. Accepted that tolerance develops in addition to the many effects of marijuana and more likely with prolonged use of high doses.

Physical dependence – is relatively weak and not always develop, so the withdrawal is also not pronounced. Psychological dependence – a strong case of chronic use.
Withdrawal syndrome

The duration of the withdrawal syndrome – from several hours to 4-5 days.
o nausea
o diarrhea
o loss of appetite, weight loss
o chills and sweating
o tremor
o unbearable pain
o insomnia
o irritability
o anxiety
o depression
o blackout

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