BRAIN. Marijuana affects the intellectual ability, the ability to understand abstract thinking, learning and the Middle memory. Depending on the strength of the means and the susceptibility of the consumer, it can cause a state of panic, anxiety, and toxic psychosis. Long-term consumption may lead to structural and functional changes.
LUNGS. Smoking marijuana causes any harmful
effects inherent in smoking: bronchitis, pharyngitis, sinusitis, lung cancer. Marijuana to a greater extent than tobacco, promotes the development of respiratory diseases and edema.
HEART. Marijuana use causes increased heart rate, increased heart rate and blood pressure increase. Smoking marijuana is especially dangerous for people suffering from heart ailments.
SYSTEM OF REPRODUCTION (men). Smoking decreases the amount of testosterone, the principal male hormone. Persistent and prolonged use can alter hormones so that disrupted the development of sexual function in adolescents. In severe cases, a decrease in sperm counts and motility and increased number of abnormal cells in the semen.
SYSTEM OF REPRODUCTION (women). Kannabino-ides accumulated in female reproductive organs. Changes in brain activity may impair ovulation and reduce fertility. Cannabinoids may have a toxic effect on fetal development, causing a variation in gestation, the heavy flow of birth and early death of infants. The so-called “fetal marijuana syndrome” characterized by low weight births and abnormalities of development, there is 5 times more often than “fetal alcohol syndrome.” Together with mother’s milk Cannabinoids go into the child’s body during feeding.
Motor functions. Smoking marijuana can affect the mental and physical reactions, disrupt the coordination and increased reaction time. Violated human response to light and sound signals, impaired ability to perform successive operations and the degree of perception. There is a strong need to move, walk, talk, characterized by unnatural posture at rest.
OTHER BODY SYSTEMS. Chronic fatigue, headaches, nausea.
The minimum dose of 5 mg THC, the effective oral dose of 50 – 200 ug / kg, the effective dose when smoked 25-50 mg / kg. Toxic dose of 0.035 mg / kg (highly dependent on tolerance). Sale “on the streets” cigarettes usually contain 300-750 mg of marijuana with a share of THC from 0.5 to 11% (sometimes up to 13-15%, in rare cases – above). Usual daily dose: 2 cigarettes per day (about 40 mg THC). In the process of smoking a large proportion of THC undergoes thermal degradation. With a deep inhalation and prolonged retention in the lung (20-30 seconds) to 50% THC enters the circulatory system, on average, bioavailability when smoking is determined by the interval 10-23%. THC binding to lipo-proteins, about 97%.
When smoking and intravenous THC concentration profiles in the plasma are similar, but in case of smoke concentration is less than half, although this value strongly depends on the skill of the smoker (puff duration, inhaled volume, delays breath after inhalation). THC enters the bloodstream for several minutes, reaching maximum plasma concentrations within 5-30 minutes. Subsequent decrease to 1-3 ng / ml occurs in 3-5 hours. Kinetics of elimination from plasma is described according to the model of two-phase elimination: “fast” – for about 40 minutes, the “slow” – up to 24 hours. The interval of concentration in the blood of 226 persons, marijuana is 0-113 ng / ml with a mean of 15.4 ng / ml. Maximum psychological effect corresponds to the maximum concentration in the blood. T (1 / 2) THC in plasma for the “fast” and “slow” phases of 3-4,5 minutes and 20 hours respectively.
With a lipophilic, after intake of THC rapidly leaves the bloodstream, is distributed in tissues rich in lipids: body fat, brain, lungs, genital organs, cell membranes. Distribution volume of 10 l / kg. Detectable quantity of THC in the body fat of the body, taken by biopsy in chronic marijuana smokers, found more than four weeks after the treatment of smoking and are 0,4-8 ng / g. Number of THC in the fat depends on the dose, frequency, and individual characteristics of the organism.
The distribution of THC in the body (death related to marijuana use) showed the THC content in body fat 657 ng / g, which is from 6 to 355 times higher than that in blood, urine and other body tissues.
Accumulated THC is slowly returning to the circulatory system and can be determined by a highly sensitive technique in the blood for several hours and in urine after 7 – 10 days after smoking a cigarette or injection of a single dose.
With regular smoking two cigarettes a week for 6 months, traces of THC can be detected several weeks after smoking cessation.